Khalsa Lab

Publications

Featured Publications

Summary: This commentary highlights how interoception plays a central role in obesity and disorders of gut-brain interaction. It arose from a two-day NIDDK-sponsored workshop at which Dr. Khalsa served as sole keynote speaker.

Summary: This randomized clinical trial shows that patients with generalized anxiety disorder exhibit heightened heart rate responses and reduced activity in the ventromedial prefrontal cortex during mild cardiac stimulation — pointing to a specific brain target for future treatments.

Summary: This study demonstrates that an ingestible vibrating capsule reliably activates specific brain regions in response to gut stimulation — providing the methodological foundation for ongoing NIH-funded studies of gut-brain dysfunction in anorexia nervosa.

Summary: A consensus roadmap from the 2016 Interoception Summit that helped to redefine interoception and its relevance to mental health [Most cited publication in the journal].

  1. Tobel T, Cone A, Choquette E, Garland M, Johnson MA, Mink K, Lynch C, Frohlich J, Feinstein JS, Reggente N, Khalsa S. Aquahenosis: a non-pharmacological altered state of consciousness induced by floatation-REST in individuals with anxiety and depression. Neurosci Conscious. 2026(1):niag044. doi: 10.1093/nc/niag044. PMID: 42657182.
  2. Lee K, Nishiyama R, Khalsa SS, Duarte A. How aging shapes interoception: A multimodal, multidimensional analysis. J Gerontol B Psychol Sci Soc Sci. 2026. doi: 10.1093/geronb/gbag169. PMID: 42625395.
  3. Paulus MP, Torous J, Perlis RH, Sarma KV, Ajilore O, Khalsa SS, Rodriguez CI. Responsible and innovative AI for mental health care: five priority themes. NPP Digit Psychiatry Neurosci. 2026 4(1). doi: 10.1038/s44277-026-00068-x. PMID: 42624890.
  4. Malik V, Roy B, Sarkar A, Shivkumar K, Khalsa S, Kumar R, Ajijola OA. Brain tissue changes, network dysfunction, and cerebral hemodynamic deficits in postural orthostatic tachycardia syndrome. Heart Rhythm. 2026 23(8):e1617-e1627. doi: 10.1016/j.hrthm.2026.02.020. PMID: 41740821.
  5. Miller-Patterson C, Safarpour D, Longardner K, Lamotte G, Lenka A, Mahajan A, Diamond S, Gupta A, Hershberg J, Khalsa S, Olshansky B, Pontone GM, Rope R, Pfeiffer RF, Subramanian I. A framework for multidisciplinary management of autonomic dysfunction in Parkinson disease. Parkinsonism Relat Disord. 2026:108905. doi: 10.1016/j.parkreldis.2026.108905. PMID: 42567797.
  6. Wilkinson EM, Jones HG, Kohler M, Khalsa S, Moseley GL, Berryman C. A Comprehensive Meta-Analytic Review of the Neurophysiological Properties of the Heartbeat Evoked Potential in Health and Disease. Biol Psychiatry Cogn Neurosci Neuroimaging. 2026. doi: 10.1016/j.bpsc.2026.04.012. PMID: 42092635.
  7. Khalsa SS, Boyle NG. Redefining ICD Aftercare: Mental Health as a Core Component of Cardiac Electrophysiology Practice. JACC Clinical Electrophysiology. 2026 12(1):156-158. doi: 10.1016/j.jacep.2025.12.005. PMID: 41589781.
  8. Grossman P, Ackland GL, Allen AM, et al., Khalsa SS, Shivkumar K, et al. Why The Polyvagal Theory Is Untenable: An international expert evaluation. Clinical Neuropsychiatry. 2026 23(1):100-112. doi: 10.36131/cnfioritieditore20260110. PMID: 41768017.
  9. Varghese C, Dachs N, Schamberg G, et al., Khalsa SS. Expert Clinical Consensus on Body Surface Gastric Mapping Phenotypes for Gastroduodenal Disorders: “Auckland Classification” v1.0. Neurogastroenterology & Motility. 2026 38(7):e70377. doi: 10.1111/nmo.70377. PMID: 42381563.
  10. Khan M, Edgcomb J, Heldt J, Yang Y, Debonis K, Richards M, Khalsa SS. Artificial Intelligence in Psychiatric Graduate Medical Education. Academic Psychiatry. 2026. doi: 10.1007/s40596-026-02406-9. PMID: 42521959.
  11. Parisi A, Taylor-Swanson L, Stewart JL, Khalsa SS, Garland EL. Enhancing interoceptive awareness in chronic pain and opioid misuse via mindfulness-oriented recovery enhancement. Drug and Alcohol Dependence. 2025 274:112741. doi: 10.1016/j.drugalcdep.2025.112741. PMID: 40482520. IF 4.5
  12. Talishinsky A, Ajijola OA, Khalsa SS. Autonomic Imbalance in Cardiomyopathy and Heart Failure: From Neurobiology to Precision Neuromodulation. Current Cardiology Reports. 2025 27(1):144. doi: 10.1007/s11886-025-02288-7. PMID: 41117884. IF 3.7
  13. Choquette EM, Garland M, Morrissey G, Wilzok N, Wilson R, Premkumar A, Steward JL, Khalsa SS. Reduced Environmental Stimulation Therapy (REST) in Methamphetamine Use Disorder: A Pilot Study. Addictive Behavior Reports 2025 23:100651. doi: 10.1016/j.abrep.2025.100651. PMID: 41560776. PMCID: PMC12813051.
  14. Zbozinek TD, Khalsa SS, Craske MG. New and emerging treatments for anxiety disorders. The British Medical Journal (BMJ). 2026 Mar 16;392:e083441. doi: 10.1136/bmj-2024-083441. PMID: 41839508. IF 93.7
  15. Verdonk C, Mink K, Choquette E, Moseman SE, Mayeli A, Stewart JL, Paulus MP, Smith R, Khalsa SS. Gastrointestinal Interoception and Relapse in Anorexia Nervosa. JAMA Psychiatry. 2026. doi: 10.1001/jamapsychiatry.2026.1301. IF 21.6
  16. Tsuchiyagaito A, Kuplicki R, Misaki M, Edwards L, Camprodon JA, Fitzgerald K, Khalsa SS, Philip NS, Paulus MP, Guinjoan SM. Reversible modulation of a deep white matter surgical target for depression with low-intensity focused ultrasound. Neuropsychopharmacology. 2025 Sep 25. doi: 10.1038/s41386-025-02252-7. PMID: 40999237. IF 7.1
  17. Lavretsky H, Khalsa S, Oughli HA, Ibanez A, Cruzat J, Edwards E, Newhouse P, Bassetti CLA, Begue I, Winkler AS, Jeste DV, Eyre HA. The Role of Brain Health and Resilience in Reshaping Trajectories of Late-Life Neuropsychiatric Disorders. Neuropsychopharmacology. 2026 Jan 28. doi: 10.1038/s41386-026-02332-2. PMID: 41606214. IF 7.1
  18. Rojas L, Mann E, Ren X, Bethel D, Baughman N, Burrows K, Kuplicki R, Figueroa-Hall LK, Aupperle RL, Stewart JL, Guinjoan SM, Khalsa SS, Savitz J, Paulus MP, Wilhelm RA, John-Henderson NA, Yeh HW, White EJ. Major depressive disorder and serum inflammatory biomarkers as predictors of reward processing dysfunction in an American Indian sample. Biol Psychiatry CNNI. 2025 9:S2451-9022(25)00263-0. doi: 10.1016/j.bpsc.2025.08.015. IF 4.8
  19. Powers AR, Khalsa SS. The Future of Perceptual Dysregulation in Psychiatric Nosology. Curr Top Behav Neurosci. 2025 Aug 13. doi: 10.1007/7854_2025_596. PMID: 40794380.
  20. Verdonk C, Ajijola OA, Khalsa SS. Toward a multidisciplinary neurobiology of interoception and mental health. Current Opinion in Neurobiology. 2025 Jul 4;94:103084. PMID: 40616883. IF 5.2
  21. Savitz J, Figueroa-Hall LK, Teague TK, Yeh HW, Zheng H, Kuplicki R, Burrows K, El-Sabbagh N, Thomas M, Ewers I, Cha YH, Guinjoan S, Khalsa SS, Paulus MP, Irwin MR. Systemic Inflammation and Anhedonic Responses to an Inflammatory Challenge in Adults With Major Depressive Disorder: A Randomized Controlled Trial. Am J Psychiatry. Jun 1;182(6):560-568. doi: 10.1176/appi.ajp.20240142. Epub 2025 Apr 23. PMID: 40264292. IF 15.1
  22. Chang L, Thaiss CA, Knight Z, Khalsa SS. Gut Feelings: The Critical Role of Interoception in Obesity and Disorders of Gut-Brain Interaction. Gastroenterology. 2025 Apr 16:S0016-5085(25)00637-7. doi: 10.1053/j.gastro.2025.04.002. PMID: 40250772. IF 25.1
  23. Nath M, Becattini V, Laukkonen, RE, Ganesan S, Hanley A, Holecek A, Simonian N, Schoeller F, Khalsa S, Sacchet M, & Reggente N.. Heartbeat-Evoked Potentials as a Neural Marker of Meditative Depth. OSF Preprints. 2025 https://doi.org/10.31219/osf.io/hpcgd_v1
  24. Lavalley CA, Mehta MM, Taylor S, Chuning AE, Stewart JL, Huys QJM, Khalsa SS, Paulus MP, Smith R. Computational mechanisms underlying multi-step planning deficits in methamphetamine use disorder. Transl Psychiatry. 2025 15:181. doi: 10.1038/s41398-025-03390-8. PMID: 40413170. IF 5.8
  25. Treves IN, Chen YY, Wilson CL, Verdonk C, Qina’au J, Pustejovsky JE, Goldberg SB, Mehling W, Schuman-Olivier Z, Khalsa SS. A meta-analysis of the effects of mindfulness meditation training on self-reported interoception. Scientific Reports. 2025 15(1):38889. doi: 10.1038/s41598-025-22661-4. PMID: 41198766. IF 4.6
  26. Goldman CM, Takahashi T, Lavalley CA, Li N, Taylor SM, Chuning AE, Hodson R, Stewart JL, Wilson RC, Khalsa SS, Paulus MP, Smith R. Individuals with methamphetamine use disorder show reduced directed exploration and learning rates independent of an aversive interoceptive state induction. Commun Psychol. 2025 Jun 7;3(1):90. doi: 10.1038/s44271-025-00269-8. PMID: 40483324.
  27. Ajijola OA, Aksu T, Arora R, Biaggioni I, Chen PS, De Ferrari G, Dusi V, Fudim M, Goldberger JJ, Green AL, Herring N, Khalsa SS, Kumar R, Lakatta E, Mehra R, Meyer C, Po S, Stavrakis S, Somers VK, Tan AY, Valderrabano M, Shivkumar K. Clinical neurocardiology: defining the value of neuroscience-based cardiovascular therapeutics – 2024 update. J Physiol. 2025 Mar;603(7):1781-1839. doi: 10.1113/JP284741. IF 4.4
  28. Li N, Lavalley CA, Chou KP, Chuning AE, Taylor S, Goldman CM, Torres T, Hodson R, Wilson RC, Stewart JL, Khalsa SS, Paulus MP, Smith R. Directed exploration is reduced by an aversive interoceptive state induction in healthy individuals but not in those with affective disorders. Mol Psychiatry. 2025 doi: 10.1038/s41380-025-02980-8. IF 9.6
  29. Choquette EM, Khalsa SS. Sensing the Self: The Role of the Insula and Interoception in Body Image. Curr Top Behav Neurosci. 2025. doi: 10.1007/7854_2025_581. IF 2.5
  30. Longardner K, Mabry SA, Chen G, Freeman R, Khalsa SS, Beach P. Interoception in Parkinson’s disease: A narrative review and framework for translational research. Auton Neurosci. 2025 259:103258. doi: 10.1016/j.autneu.2025.103258. Epub 2025 Mar 8. PMID: 40101537. IF 3.3
  31. Ganesan S, Barrios FA, Batta I, Bauer CCC, Braver TS, Brewer JA, Brown KW, Cahn R, Cain JA, Calhoun VD, Cao L, Chetelat G, Ching CRK, Creswell JD, Dagnino PC, Davanger S, Davidson RJ, Deco G, Dutcher JM, Escrichs A, Eyler LT, Fani N, Farb NAS, Fialoke S, Fresco DM, Garg R, Garland EL, Goldin P, Hafeman DM, Jahanshad N, Kang Y, Khalsa SS, Kirlic N, Lazar SW, Lutz A, McDermott TJ, Pagnoni G, Piguet C, Prakash RS, Rahrig H, Reggente N, Saccaro LF, Sacchet MD, Siegle GJ, Tang Y-Y, Thomopoulos SI, Thompson PM, Torske A, Treves IN, Tripathi V, Tsuchiyagaito A, Turner MD, Vago DR, Valk S, Zeidan F, Zalesky A, Turner JA & King AP, ENIGMA-Meditation: Worldwide consortium for neuroscientific investigations of meditation practices, Biological Psychiatry: Cognitive Neuroscience and Neuroimaging. 2025 10(4):425-436. doi: 10.1016/j.bpsc.2024.10.015. Epub 2024 Nov 6. PMID: 39515581. IF 4.8
  32. Adamic EM, Teed AR, Avery J, de la Cruz F, Khalsa S. Hemispheric divergence of interoceptive processing across psychiatric disorders. Elife. 2024 13:RP92820. doi: 10.7554/eLife.92820. PMID: 39535878. IF 6.4
  33. Strohman A, Isaac G, Payne B, Verdonk C, Khalsa SS, Legon W. Low-intensity focused ultrasound to the human insular cortex differentially modulates the heartbeat-evoked potential: a proof-of-concept study. Clin Neurophysiology. 2024 S1388-2457(24)00265-7. doi: 10.1016/j.clinph.2024.09.006. IF 3.7
  34. Munshi S, Alarbi AM, Zheng H, Kuplicki R, Burrows K, Figueroa-Hall LK, Victor TA, Aupperle RL, Khalsa SS, Paulus MP, Teague TK, Savitz J. Increased expression of ER stress, inflammasome activation, and mitochondrial biogenesis-related genes in peripheral blood mononuclear cells in major depressive disorder. Mol Psychiatry. 2025 Feb;30(2):574-586. doi: 10.1038/s41380-024-02695-2. PMID: 39174649; PMCID: PMC12054637. IF 9.6
  35. Ritz T, Schulz A, Khalsa S. The golden age of integrative neuroscience? The brain joins the body in the latest renaissance of interoception research. Biol Psychology. 2024 192:108851. doi: 10.1016/j.biopsycho.2024.108851. PMID: 39069198. IF 3.3
  36. Sojka P, Serranová T, Khalsa SS, Perez DL, Diez I. Altered Neural Processing of Interoception in Patients With Functional Neurological Disorder: A Task-Based fMRI Study. The Journal of Neuropsychiatry and Clinical Neurosciences. 2025 37(2):149-159. doi: 10.1176/appi.neuropsych.20240070. PMID: 39558709. IF 2.4
  37. Poplin T, Ironside M, Kuplicki R, Aupperle R, Guinjoan S, Khalsa SS, Stewart JL, Victor T, Paulus MP, Kirlic N. The unique face of comorbid anxiety and depression: Increased sustained threat circuitry response during fear acquisition. Journal of Affective Disorders 2024 366:98-105. doi: 10.1016/j.jad.2024.08.143. PMID: 39187192. IF 4.9
  38. Law M, Pickering I, Humphrey G, Sebaratnam G, Schamberg G, Simpson K, Varghese C, Du P, Daker C, Huang IH, Khalsa SS, Gharibans A, O’Grady G, Andrews CN, Calder S. Development and validation of the Alimetry Gut-Brain Wellbeing Survey: a novel patient-reported mental health scale for patients with chronic gastroduodenal symptoms. Front Psychol. 2024 15:1389671. doi: 10.3389/fpsyg.2024.1389671. PMID: 39040963. IF 2.6
  39. Lavalley CA, Hakimi N, Taylor S, Kuplicki R, Forthman KL, Stewart JL, Paulus MP, Khalsa SS, Smith R. Transdiagnostic failure to adapt interoceptive precision estimates across affective, substance use, and eating disorders: A replication and extension of previous results. Biol Psychology. 2024 191:108825. doi: 10.1016/j.biopsycho.2024.108825. PMID: 38823571. IF 3.3
  40. Zhang Y, Munshi S, Burrows K, Kuplicki R, Figueroa-Hall LK, Aupperle RL, Khalsa SS, Teague TK, Taki Y, Paulus MP, Savitz J, Zheng H. Leptin’s Inverse Association With Brain Morphology and Depressive Symptoms: A Discovery and Confirmatory Study Across 2 Independent Samples. Biol Psychiatry CNNI 2024 9(7):714-725. doi: 10.1016/j.bpsc.2024.04.005. PMID: 38631553. IF 5.7
  41. Burrows K, Figueroa-Hall LK, Stewart JL, Alarbi AM, Kuplicki R, Hannafon BN, Tan C, Risbrough VB, McKinney BA, Ramesh R, Victor TA, Aupperle R, Savitz J, Teague TK, Khalsa SS, Paulus MP. Exploring the role of neuronal-enriched extracellular vesicle miR-93 and interoception in major depressive disorder. Transl Psychiatry. 2024 14(1):199. doi: 10.1038/s41398-024-02907-x. PMID: 38678012. IF 6.8
  42. Strohman A, Isaac G, Payne B, Verdonk C, Khalsa SS, Legon W. Low-intensity focused ultrasound to the human insular cortex differentially modulates the heartbeat-evoked potential: a proof-of-concept study. bioRxiv. 2024 doi: 10.1101/2024.03.08.584152. PMID: 38559271.
  43. Morrissey G, Tsuchiyagaito A, Takahashi T, McMillin J, Aupperle RL, Misaki M, Khalsa SS. Could neurofeedback improve therapist-patient communication? Considering the potential for neuroscience informed examinations of the psychotherapeutic relationship. Neurosci Biobehav Rev. 2024 161:105680. doi: 10.1016/j.neubiorev.2024.105680. PMID: 38641091. IF 8.2
  44. Garland MM, Wilson R, Thompson WK, Stein MB, Paulus MP, Feinstein JS, Khalsa SS. A randomized controlled safety and feasibility trial of floatation-REST in anxious and depressed individuals. PLoS One. 2024 19(6):e0286899. doi: 10.1371/journal.pone.0286899. PMID: 38843272. IF 2.9
  45. Obradovich N, Khalsa, SS*, Khan, WU, Suh J, Perlis R, Ajilore O, Paulus MPP.Opportunities and risks of large language models in psychiatry. NPP—Digital Psychiatry Neuroscience 2, 1-8. https://doi.org/10.1038/s44277-024-00010-z
  46. Adamic EM, Teed AR, Avery JA, de la Cruz F, Khalsa SS. Hemispheric divergence of interoceptive processing across psychiatric disorders. eLife Registered Preprint. 2024 doi: https://doi.org/10.7554/eLife.92820.1. PMID: 38105986. IF 7.7
  47. Verdonk C, Teed AR, White EJ, Ren X, Stewart JL, Paulus MP, Khalsa SS. Heartbeat-evoked neural response abnormalities in generalized anxiety disorder during peripheral adrenergic stimulation. Neuropsychopharmacology. 2024 doi: 10.1038/s41386-024-01806-5. PMID: 38291167. IF 7.6
  48. Sojka P, Serranová T, Khalsa SS, Perez DL, Diez I. Interoceptive disruption in functional neurological disorder: a multimodal brain imaging study. MedRxiv. 2024 doi: 10.1101/2024.03.13.24303546.
  49. Munshi S, Alarbi A, Zheng H, Kuplicki R, Burrows K, Figueroa-Hall L, Victor T, Aupperle R, Khalsa S, Paulus M, Teague TK, Savitz J. Increased expression of ER stress, inflammasome activation, and mitochondrial biogenesis-related genes in peripheral blood mononuclear cells in major depressive disorder. Research Square. 2024 rs.3.rs-3564760. doi: 10.21203/rs.3.rs-3564760/v1. PMID: 38260352;
  50. Richards J, Khalsa SS. Highway to the danger zone? A cautionary account that GLP-1 receptor agonists may be too effective for unmonitored weight loss. Obesity Reviews. 2024 e13709. doi: 10.1111/obr.13709. PMID: 38320760. IF 10.9
  51. Rajendran PS, Haday J, Khalsa SS, Yu C, Chang R, Shivkumar S. The vagus nerve in cardiovascular physiology and pathophysiology: From evolutionary insights to clinical medicine. Seminars in Cell & Developmental Biology. 2024 Mar 15;156:190-200. doi: 10.1016/j.semcdb.2023.01.001. PMID: 36641366. IF 7.5
  52. Bischoff H, Kovach C, Kumar S, Bruss J, Tranel D, Khalsa SS. Sensing, Feeling, and Regulating: Investigating the Association of Focal Brain Damage with Voluntary Respiratory and Motor Control. bioRxiv. 2023 doi: 10.1101/2023.10.16.562254.
  53. Lavalley CA, Hakimi N, Taylor S, Kuplicki R, Forthmann KL, Stewart JL, Paulus MP, Khalsa SS, Smith R. Transdiagnostic failure to adapt interoceptive precision estimates across affective, substance use, and eating disorders: A replication study. MexRxiv 2023 doi: 10.1101/2023.10.11.23296870v1.
  54. Khalsa SS. Rhythms of the Heart, Echoes in the Brain: Exploring Interoception. JACC (Journal of the American College of Cardiology): Clinical Electrophysiology. 2023 Nov;9(11):2236-2239. doi: 10.1016/j.jacep.2023.09.001. PMID: 37855768. IF 6.4
  55. Choquette EC, Flux MC, Moseman SE, Chappelle S, Naegele J, Upshaw V, Morton A, Paulus MP, Feinstein JS, Khalsa SS. The impact of floatation therapy on body image and anxiety in anorexia nervosa: a randomised clinical efficacy trial. EClinicalMedicine. 2023 64: 102173 doi: 10.1016/j.eclinm.2023.102173. IF 15.1
  56. Richards J, Bang N, Ratliff E, Paszkowiak MA, Khorgami Z, Khalsa SS, Simmons K. Successful treatment of binge eating disorder with the GLP-1 agonist semaglutide: a retrospective cohort study. Obesity Pillars. 2023 doi: 10.1016/j.obpill.2023.100080.
  57. Burrows K, McNaughton B, Figueroa-Hall LK, Spechler P, Kuplicki R, Victor T, Aupperle RL, Khalsa SS, Savitz J, Teague TK, Paulus MP, Stewart JL. Elevated serum leptin is associated with attenuated reward anticipation in major depressive disorder independent of peripheral C-reactive protein levels. Scientific Reports. 2023 13(1):11313. doi: 10.1038/s41598-023-38410-4. PMID: 37443383. IF 5.0
  58. Mayeli A, Al Zoubi O, White EJ, Chappelle S, Kuplicki R, Morton A, Bruce J, Smith R, Feinstein JS, Bodurka J, Paulus MP, Khalsa SS. Parieto-occipital ERP indicators of gut mechanosensation. Nature Communications. 2023 14: 3398. doi: 10.1038/s41467-023-39058-4. PMID: 37311748. IF 17.7
  59. Steinhäuser JL, Teed AR, Al-Zoubi O, Hurlemann R, Chen G, Khalsa SS. Reduced vmPFC-insula functional connectivity in generalized anxiety disorder: a Bayesian confirmation study. Scientific Reports.2023 13: 9626. doi: 10.1038/s41598-023-35939-2. IF 5.0
  60. Garland MM, Wilson R, Adamic E, Thompson WK, Arevian AC, Stein MB, Paulus MP, Feinstein JS, Khalsa SS. Reduced Environmental Stimulation Therapy (REST) in anxiety and depression: An experience sampling study. Journal of Mood and Anxiety Disorders. 2023 1: 100003. doi: 10.1016/j.xjmad.2023.100003
  61. Joshi SA, Aupperle RL, Khalsa SS. Interoception in fear learning and PTSD. 2023 21:266-277. doi: 10.1176/appi.focus.20230007. PMID: 37404967. IF 4.7
  62. Garland MM, Wilson R, Thompson WK, Stein MB, Paulus MP, Feinstein JS, Khalsa SS. A randomized controlled safety and feasibility trial of floatation-REST in anxious and depressed individuals. MedRxiv. 2023 doi: 10.1101/2023.05.27.23290633. PMID: 37333146.
  63. Verdonk C, Teed AR, White EJ, Ren X, Stewart JL, Paulus MP, Khalsa SS. Heartbeat-evoked neural response abnormalities in generalized anxiety disorder during peripheral adrenergic stimulation. 2023 doi: 10.1101/2023.06.09.23291166. PMID: 37398268.
  64. Wilzok N, Adamic EM, Khalsa SS, Croy, I. Multidimensional assessment of anticipated and experienced interoceptive states. Physiology & Behavior. 2023 269: 114265. doi: 10.1016/j.physbeh.2023.114265. PMID: 37301492. IF 3.7
  65. Smith R, Lavalley CA, Taylor S, Stewart JL, Khalsa SS, Berg H, Ironside M, Paulus MP, Aupperle R. Elevated decision uncertainty and reduced avoidance drives in depression, anxiety and substance use disorders during approach-avoidance conflict: a replication study. J Psychiatry Neurosci. 2023 48:E217-E231. doi: 10.1503/jpn.220226. PMID: 37339816. IF 5.7
  66. Forthman KL, Kuplicki R, Yeh HW, Khalsa SS, Paulus MP, Guinjoan SM. Transdiagnostic behavioral and genetic contributors to repetitive negative thinking: A machine learning approach. J Psychiatr Res. 2023 62:207-213. doi: 10.1016/j.jpsychires.2023.05.039. PMID: 37178517. IF 5.3
  67. Stewart JL, Burrows K, Davis CB, Wilhelm RA, McNaughton BA, Kuplicki R, Paulus MP, Khalsa SS, White EJ. Impulsivity in amphetamine use disorder: Examination of sex differences. 2023 118(9):1787-1800. doi: 10.1111/add.16225. PMID: 37132044. IF 7.1
  68. De la Cruz F, Teed AR, Lapidus RC, Upshaw V, Schumann A, Paulus MP, Bär KJ, Khalsa SS. Central autonomic network alterations in anorexia nervosa following peripheral adrenergic stimulation. Biological Psychiatry: Cognitive Neuroscience and Neuroimaging. 2023 8(7):720-730. doi: 10.1016/j.bpsc.2022.12.009. PMID: 37055325. IF 6.2
  69. Ironside M, DeVille DC, Kuplicki R, Burrows KP, Smith R, Teed AR, Paulus MP, Khalsa SS. The unique face of comorbid anxiety and depression: Increased interoceptive fearfulness and reactivity. Frontiers in Behavioral Neuroscience. 2023 16:1083357. doi: 10.3389/fnbeh.2022.1083357. PMID: 36755667. IF 3.6
  70. Burrows K, Figueroa-Hall LK, Alarbi AM, Stewart JL, Kuplicki R, Tan C, Hannafon BN, Ramesh R, Savitz J, Khalsa S, Teague TK, Risbrough VB, Paulus MP. Association between inflammation, reward processing, and ibuprofen-induced increases of miR-23b in astrocyte-enriched extracellular vesicles: A randomized, placebo-controlled, double-blind, exploratory trial in healthy individuals. Brain, Behavior, & Immunity – Health. 27:100582. doi: 10.1016/j.bbih.2022.100582. PMID: 36605933.
  71. Guinjoan S, Tsuchiyagaito A, Khalsa S, Kuplicki R, Sanchez S, Park H, Misaki M, Rohan M, Paulus MP. Effect of low-intensity focused ultrasound of right anteromedial cortico-subcortical circuits on repetitive negative and self-referential thinking in depression: a sham-controlled randomized feasibility trial. Research Square Preprints. 2022 doi: 10.21203/rs.3.rs-2338430/v1
  72. Choquette EC, Flux MC, Moseman SE, Chappelle S, Naegele J, Upshaw V, Morton A, Paulus MP, Feinstein JS, Khalsa SS. The impact of floatation therapy on body image and anxiety in anorexia nervosa: a randomized clinical efficacy trial. 2023 Preprints with THE LANCET. doi: 10.2139/ssrn.4285497
  73. Smits JA, Monfils M, Otto MW, Telch MJ, Shumake J, Feinstein JS, Khalsa SS, Cobb AR, Parsons EM, Long LJ, McSpadden B, Johnson D, Greenberg A, Exposure Therapy Consortium. CO2 Reactivity as a Biomarker of Exposure-based Therapy Non-Response: Study Protocol. BMC Psychiatry. 2022 22:831. doi: 10.1186/s12888-022-04478-x. PMID: 36575425. IF 3.4
  74. Flux MC, Fine TH, Poplin T, Al Zoubi O, Schoenhals WA, Schettler J, Refai H, Naegele J, Wohlrab C, Yeh H, Lowry CA, Levine JC, Smith R, Khalsa SS, Feinstein JS. Exploring the acute cardiovascular effects of Floatation-REST. Front Neurosci. 2022 16:995594. doi: 10.3389/fnins.2022.995594. PMID: 36570829. IF 4.5
  75. Khalsa SS, Verdonk C. Atrial fibrillation as a disorder of heart-brain communication. JACC (Journal of the American College of Cardiology): Clinical Electrophysiology. 2022, 8:10: 1231-33. IF 6.4.
  76. Savitz J, Ford BN, Kuplicki R, Khalsa SS, Teague TK, Paulus MP. Acute administration of ibuprofen increases serum concentration of the neuroprotective kynurenine pathway metabolite, kynurenic acid: a pilot randomized, placebo-controlled, cross-over study. 2022 239(12):3919-3927. doi: 10.1007/s00213-022-06263-w. PMID: 36271950. IF 4.4
  77. Park H, Sanchez SM, Kuplicki R, Tsuchiyagaito A, Tulsa 1000 investigators, Khalsa SS, Paulus MP, Guinjoan SM. Attenuated interoceptive processing in individuals with major depressive disorder and high repetitive negative thinking. Journal of Psychiatric Research. 2022, 156:237-244. Doi: 10.1016/j.jpsychires.2022.10.020. PMID: 36270063. IF 4.8
  78. Williamson S, Daniel-Watanabe L, Finnemann J, Powell C, Teed A, Allen M, Paulus M, Khalsa SS, Fletcher PC. The Hybrid Excess and Decay (HED) model: an automated approach to characterising changes in the photoplethysmography pulse waveform. Wellcome Open Research.2022 7:214. doi: 10.12688/wellcomeopenres.17855.1
  79. Fani N, Khalsa SS. The role of racial discrimination in dissociation and interoceptive dysfunction. 2022 Aug 3. doi: 10.1038/s41386-022-01402-5. PMID: 35922550. IF 8.3
  80. Zheng H, Kent Teague T, Yeh FC, Burrows K, Figueroa-Hall LK, Aupperle RL, Khalsa SS, Paulus MP, Savitz J. C-Reactive Protein and the Kynurenic Acid to Quinolinic Acid Ratio are Independently Associated with White Matter Integrity in Major Depressive Disorder. Brain Behavior Immunity. 2022 16:S0889-1591(22)00185-4. doi: 10.1016/j.bbi.2022.07.011. IF 19.2
  81. Walton E, Bernardoni F, Batury VL, Bahnsen K, Larivière S, Abbate-Daga G, Andres-Perpiña S, Bang L, Bischoff-Grethe A, Brooks SJ, Campbell IC, Cascino G, Castro-Fornieles J, Collantoni E, D’Agata F, Dahmen B, Danner UN, Favaro A, Feusner JD, Frank GKW, Friederich HC, Graner JL, Herpertz-Dahlmann B, Hess A, Horndasch S, Kaplan AS, Kaufmann LK, Kaye WH, Khalsa SS, LaBar KS, Lavagnino L, Lazaro L, Manara R, Miles AE, Milos GF, Monteleone AM, Monteleone P, Mwangi B, O’Daly O, Pariente J, Roesch J, Schmidt UH, Seitz J, Shott ME, Simon JJ, Smeets PAM, Tamnes CK, Tenconi E, Thomopoulos SI, van Elburg AA, Voineskos AN, von Polier GG, Wierenga CE, Zucker NL, Jahanshad N, King JA, Thompson PM, Berner LA, Ehrlich S. Brain Structure in Acutely Underweight and Partially Weight-Restored Individuals With Anorexia Nervosa: A Coordinated Analysis by the ENIGMA Eating Disorders Working Group. Biological Psychiatry. 2022 92(9):730-738. doi: 10.1016/j.biopsych.2022.04.022. IF 13.4
  82. Burrows K, DeVille DC, Cosgrove KT, Kuplicki RT; Tulsa 1000 Investigators; Paulus MP, Aupperle R, Khalsa SS, Stewart JL. Impact of serotonergic medication on interoception in major depressive disorder. Biol Psychol. 2022 169:108286. doi: 10.1016/j.biopsycho.2022.108286. PMID: 35149138.
  83. Kirlic N, Kuplicki R, Touthang J, Cohen ZP, Stewart JL, Tulsa 1000 Investigators†, Paulus MP, Aupperle RL. Behavioral and Neural Responses during Fear Conditioning and Extinction in a Large Transdiagnostic Sample. Neuroimage: Clinical. 2022 35:103060. doi: 10.1016/j.nicl.2022.103060. †Tulsa 1000 Investigator. IF 4.9
  84. Khalsa SS, Victor TA, Kuplicki R, Yeh HW, Vanover KE, Paulus MP, Davis RE. Single doses of a highly selective inhibitor of phosphodiesterase 1 (lenrispodun) in healthy volunteers: a randomized pharmaco-fMRI clinical trial. Neuropsychopharmacology. 2022 47(10):1844-1853. doi: 10.1038/s41386-022-01331-3. PMID: 35488084. IF 8.3
  85. Feinstein JS, Gould D, Khalsa SS. Amygdala-driven apnea and the chemoreceptive origin of anxiety. Biological Psychology. 2022 170:108305. doi: 10.1016/j.biopsycho.2022.108305. IF 3.3
  86. Park H, Kirlic N, Kuplicki R; Tulsa 1000 Investigators†, Paulus M, Guinjoan SM. Neural Processing Dysfunctions During Fear Learning but Not Reward-Related Processing Characterize Depressed Individuals With High Levels of Repetitive Negative Thinking. Biological Psychiatry: Cognitive Neuroscience and Neuroimaging. 2022 S2451-9022(22)00018-0. doi: 10.1016/j.bpsc.2022.01.002. PMID: 35065290. †Tulsa 1000 Investigator. IF 6.2
  87. Cardenas G, White EJ, Kirlic N, Tulsa 1000 Investigators†, Paulus MP, Guinjoan SM: Repetitive negative thinking is associated with impaired verbal learning but not executive functioning in individuals with eating disorders. Personalized Med Psychiatry. 2022 31-32: 100090. †Tulsa 1000 Investigator.
  88. Teed AR, Feinstein JS, Puhl M, Lapidus RC, Upshaw V, Kuplicki RT, Bodurka J, Ajijola OA, Kaye WH, Thompson WK, Paulus MP, Khalsa SS. Association of Generalized Anxiety Disorder With Autonomic Hypersensitivity and Blunted Ventromedial Prefrontal Cortex Activity During Peripheral Adrenergic Stimulation: A Randomized Clinical Trial. JAMA Psychiatry. 2022 79(4):323-332. doi: 10.1001/jamapsychiatry.2021.4225. PMID: 35107563. IF 21.6
  89. Khalsa SS, Berner L, Anderson LM. Gastrointestinal interoception in eating disorders: charting a new path. Current Psychiatry Reports. 2022 24(1):47-60. doi: 10.1007/s11920-022-01318-3. PMID: 35061138. IF 5.3
  90. Al Zoubi O, Mayeli A, Misaki M, Tsuchiyagaito A, Zotev V, Tulsa 1000 Investigators†, Refai H, Paulus M, Bodurka J. Canonical EEG microstates transitions reflect switching among BOLD resting state networks and predict fMRI signal. J Neural Eng. 2022 18(6). doi: 10.1088/1741-2552/ac4595. PMID: 34937003. †Tulsa 1000 Investigator. IF 6.4
  91. MacGregor T, Savitz J, Zhang Y, Burrows K, Smith R, Figueroa-Hall L, Kuplicki R Yeh F, Khalsa SS, Taki Y, Teague TK, Irwin MR, Paulus MP, Zheng H, and on behalf of Tulsa 1000 Investigators. Elevated systemic inflammation is associated with reduced corticolimbic white matter integrity in depression. Life 2022, 12, 43. doi: 10.3390/life12010043. IF 3.8
  92. Paulus MP, Kuplicki R, Victor TA, Yeh H, Khalsa SS. Methylphenidate augmentation of escitalopram to enhance adherence to antidepressant treatment: a pilot randomized controlled trial. BMC Psychiatry 2021 21(1):582. doi: 10.1186/s12888-021-03583-7. PMID: 34798853. IF 3.6
  93. White EJ, Kuplicki R, Stewart JL, Kirlic N, Yeh HW, Tulsa 1000 Investigators†, Paulus MP, Aupperle RL. Latent variables for region of interest activation during the monetary incentive delay task. Neuroimage. 2021 Apr 15;230:117796. doi: 10.1016/j.neuroimage.2021.117796. PMID: 33503481. †Tulsa 1000 Investigator. IF 6.6
  94. Park H, Forthman KL, Kuplicki R, Victor TA, Tulsa 1000 Investigators†, Yeh HW, Thompson WK, Paulus MP. Polygenic risk for neuroticism moderates response to gains and losses in amygdala and caudate: Evidence from a clinical cohort. J Affective Disorders. 2021 Oct 1;293:124-132. doi: 10.1016/j.jad.2021.06.016. PMID: 34186230. †Tulsa 1000 Investigator. IF 4.8
  95. Paulus MP, Khalsa SS. When you don’t feel right inside: homeostatic dysregulation and the mid-insular cortex in psychiatric disorders. American Journal of Psychiatry 2021 Aug 1;178(8):683-685. doi: 10.1176/appi.ajp.2021.21060622. PMID: 34383566. IF: 18.1
  96. Smith R, Mayeli A, Taylor S, Al Zoubi O, Naegele J, Khalsa SS. Gut inference: A computational modelling approach. Biological Psychology 2021 Jul 24;164:108152. doi: 10.1016/j.biopsycho.2021.108152. PMID: 34311031. IF: 3.3
  97. Ralph-Nearman C, Arevian AC, Moseman S, Sinik M, Chappelle S, Feusner JD, Khalsa SS. Visual mapping of body image disturbance in anorexia nervosa reveals objective markers of illness severity. Scientific Reports 2021 Jun 10;11(1):12262. doi: 10.1038/s41598-021-90739-w. PMID: 34112818. IF: 4.6
  98. Kuplicki R, Touthang J, Al Zoubi O, Mayeli A, Misaki M; NeuroMAP-Investigators†, Aupperle RL, Teague TK, McKinney BA, Paulus MP, Bodurka J. Common Data Elements, Scalable Data Management Infrastructure, and Analytics Workflows for Large-Scale Neuroimaging Studies. Front Psychiatry. 2021 Jun 17;12:682495. doi: 10.3389/fpsyt.2021.682495. PMID: 34220587. †NeuroMAP-Investigator. IF 4.2
  99. Smith R, Kirlic N, Stewart JL, Touthang J, Kuplicki R, McDermott TJ, Taylor S, Khalsa SS, Paulus MP, Aupperle RL. Long-term stability of computational parameters during approach-avoidance conflict in a transdiagnostic psychiatric patient sample. Scientific Reports. 2021 Jun 3;11(1):11783. doi: 10.1038/s41598-021-91308-x. PMID: 34083701. IF: 4.6
  100. Zheng H, Bergamino M, Ford BN, Kuplicki R, Yeh FC, Bodurka J, Burrows K; Tulsa 1000 Investigators†, Hunt PW, Teague TK, Irwin MR, Yolken RH, Paulus MP, Savitz J. Replicable association between human cytomegalovirus infection and reduced white matter fractional anisotropy in major depressive disorder Neuropsychopharmacology 2021 Apr;46(5):928-938. doi: 10.1038/s41386-021-00971-1. Epub 2021 Jan 26. PMID: 33500556. †Tulsa 1000 Investigator. IF 7.9
  101. Kosciolek T, Victor TA, Kuplicki R, Rossi M, Estaki M, Ackermann G, Tulsa 1000 Investigators†, Knight R, Paulus MP. Individuals with substance use disorders have a distinct oral microbiome pattern. Brain, Behavior, & Immunity – Health 2021 May 29;15:100271. doi: 10.1016/j.bbih.2021.100271. PMID: 34589776. †Tulsa 1000 Investigator.
  102. Cosgrove KT, Kuplicki R, Savitz J, Burrows K, Simmons WK, Khalsa SS, Teague TK, Aupperle RL, Paulus MP. Impact of ibuprofen and peroxisome proliferator-activated receptor gamma on emotion-related neural activation: A randomized, placebo-controlled trial. Brain Behav Immun. 2021 Aug;96:135-142. doi: 10.1016/j.bbi.2021.05.023. Epub 2021 May 27. PMID: 34052365; PMCID: PMC8319138. IF: 7.2.
  103. May AC, Burrows K, Figueroa-Hall LK, Kirlic N, White EJ, Smith R, Ekhtiari H, Tulsa 1000 Investigators†, Paulus MP, Savitz J, Stewart JL. Sex differences in circulating inflammatory mediators as a function of substance use disorder. Drug Alcohol Depend. 2021 Apr 1;221:108610. doi: 10.1016/j.drugalcdep.2021.108610. PMID: 33631550. †Tulsa 1000 Investigator. IF 4.5
  104. Al Zoubi O, Misaki M, Bodurka J, Kuplicki R, Wohlrab C, Schoenhals WA, Refai HH, Khalsa SS, Stein MB, Paulus MP, Feinstein JS. Taking the body off the mind: Decreased functional connectivity between somatomotor and default-mode networks following Floatation-REST. Hum Brain Mapp. 2021 42(10):3216-3227. doi: 10.1002/hbm.25429. PMID: 33835628. IF: 5.0
  105. Burrows K, Stewart JL, Kuplicki R, Figueroa-Hall L, Spechler PA, Zheng H, Guinjoan SM; Tulsa 1000 Investigators†, Savitz JB, Kent Teague T, Paulus MP. Elevated peripheral inflammation is associated with attenuated striatal reward anticipation in major depressive disorder. Brain Behav Immun. 2021 93:214-225. doi: 10.1016/j.bbi.2021.01.016. PMID: 33508469. †Tulsa 1000 Investigator. IF: 7.2
  106. DeVille DC, Khalsa SS, Tulsa 1000 Investigators, Lapidus R, White E, Paulus MP, Aupperle R. A transdiagnostic multi-level examination of interoceptive processing in individuals with a remote history of suicidal behavior. Behavior Therapy 2021 Sep;52(5):1080-1092. doi: 10.1016/j.beth.2021.01.006. PMID: 34452663 IF: 4.2
  107. Smith R, Kirlic N, Stewart JL, Touthang J, Kuplicki R, Khalsa SS, Feinstein J, Paulus MP, Aupperle RL. Greater decision uncertainty characterizes a transdiagnostic patient sample during approach-avoidance conflict: a computational modelling approach. J Psychiatry Neurosci. 2021 Jan 4;46(1):E74-E87. doi: 10.1503/jpn.200032. PMID: 33119490. IF: 6.2
  108. Khalsa SS, Clausen AN, Shahabi L, Sorg J, Gonzalez SE, Naliboff B, Shivkumar K, Ajijola O. Cardiac sympathetic denervation and mental health. Autonomic Neuroscience 2021 232:102787. doi: 10.1016/j.autneu.2021.102787. PMID: 33631539. IF: 3.1
  109. Smith R, Feinstein JS, Kuplicki R, Forthman KL, Stewart JL, Paulus MP, Tulsa 1000 Investigators, Khalsa SS. Perceptual insensitivity to the modulation of interoceptive signals in depression, anxiety, and substance use disorders. Scientific Reports Jan 22;11(1):2108. doi: 10.1038/s41598-021-81307-3. PMID: 33483527. IF: 4.6
  110. Petzschner FH, Garfinkel SN, Paulus MP, Koch C, Khalsa SS. Computational models of interoception and body regulation. Trends in Neurosciences 2021 Jan;44(1):63-76. doi: 10.1016/j.tins.2020.09.012. PMID: 33378658. IF: 13.8
  111. Berntson GG, Khalsa SS. Neural circuits of interoception. Trends in Neurosciences 2021 Jan;44(1):17-28. doi: 10.1016/j.tins.2020.09.011. PMID: 33378653. IF: 13.8
  112. Mai-Lippold SA, Dettlinger CM, Khalsa SS, Pollatos O. A pilot study on the effect of an energy drink on interoception in high vs. low anxiety sensitivity individuals. European Journal of Health Psychology (2020), 27, pp. 171-187. https://doi.org/10.1027/2512-8442/a000061
  113. Zheng H, Ford B, Bergamino M, Kuplicki R, Tulsa 1000 Investigators†, Hunt P, Bodurka J, Teague K, Irwin M, Yolken R, Paulus M, Savitz J. A Hidden Menace? Cytomegalovirus infection is associated with reduced cortical gray matter volume in major depressive disorder. Molecular Psychiatry 2020 doi: 10.1038/s41380-020-00932-y. PMID: 33223520. †Tulsa 1000 Investigator. IF: 12.5
  114. Smith R, Kuplicki R, Feinstein JS, Forthman KL, Stewart JL, Paulus MP, Tulsa 1000 Investigators, Khalsa SS. A Bayesian computational model reveals a failure to adapt interoceptive precision estimates across depression, anxiety, eating, and substance use disorders. PLoS Computational Biology 2020 Dec 14;16(12):e1008484. doi: 10.1371/journal.pcbi.1008484. PMID: 33315893. IF: 4.7
  115. Spechler PA, Stewart JL, Kuplicki R, Paulus MP; Tulsa 1000 Investigators†. Parsing impulsivity in individuals with anxiety and depression who use Cannabis. Drug Alcohol Depend. 2020 Dec 1;217:108289. doi: 10.1016/j.drugalcdep.2020.108289. PMID: 33002704. †Tulsa 1000 Investigator. IF: 4.0
  116. Tsuchiyagaito A, Misaki M, Zoubi OA; Tulsa 1000 Investigators†, Paulus M, Bodurka J. Prevent breaking bad: A proof of concept study of rebalancing the brain’s rumination circuit with real-time fMRI functional connectivity neurofeedback. Human Brain Mapping 2020 Nov 10. doi: 10.1002/hbm.25268. PMID: 33169903. †Tulsa 1000 Investigator. IF 5.0
  117. Khalsa SS, Moseman SE, Yeh H, Upshaw V, Persac B, Breese E, Lapidus RC, Chappelle S, Paulus MP, Feinstein JS. Reduced environmental stimulation therapy in anorexia nervosa: an early phase clinical trial. Frontiers in Psychology 2020 Oct 6;11:567499. doi: 10.3389/fpsyg.2020.567499. PMID: 33123048. IF: 3.0
  118. Drane DL*, Fani N*, Hallet M*, Khalsa SS*, Perez DL*, Roberts NA*. A framework for understanding the pathophysiology of functional neurological disorder. CNS Spectrums 2020 Sep 4:1-7. doi: 10.1017/S1092852920001789. PMID: 32883381 *Authors contributed equally and are listed alphabetically. IF: 3.8
  119. Moradi M, Ekhtiari H, Kuplicki R, McKinney B, Stewart JL, Victor TA, Tulsa 1000 Investigators†, Paulus MP. Resource allocation index as a potential fMRI-based biomarker for substance use disorder. Drug and Alcohol Dependence 2020 Nov 1;216:108211. doi: 10.1016/j.drugalcdep.2020.108211. PMID: 32805548. †Tulsa 1000 Investigator. IF: 4.5
  120. Smith R, Schwartenbeck P, Stewart JL, Kuplicki R, Ekhtiari H, Paulus MP, Tulsa 1000 Investigators†. Imprecise action selection in substance use disorder: Evidence for active learning impairments when solving the explore-exploit dilemma. Drug and Alcohol Dependence 2020 215: 108208. †Tulsa 1000 Investigator. doi: 10.1016/j.drugalcdep.2020.108208. PMID: 32801113. IF: 4.5
  121. Ralph-Nearman C, Yeh HW, Khalsa SS, Feusner JD, Filik R. What is the relationship between body mass index and eating disorder symptomatology in female fashion models? Psychiatry Research Nov;293:113358. doi: 10.1016/j.psychres.2020.113358. PMID: 32798930. IF: 3.2
  122. Smith R, Smith R, Kuplicki R, Teed A, Upshaw V, Khalsa SS. Confirmatory evidence that healthy individuals can adaptively adjust prior expectations and interoceptive precision estimates. In: Verbelen T, Lanillos P, Buckley C, De Boom C, editors. Active Inference IWAI 2020. Communications in Computer and Information Science, vol 1326: Springer, 2020.
  123. Spechler PA, Stewart JL, Kuplicki R; Tulsa 1000 Investigators†, Paulus MP. Attenuated reward activations associated with cannabis use in anxious/depressed individuals. Translational Psychiatry. 2020 Jun 15;10(1):189. doi: 10.1038/s41398-020-0807-9. PMID: 32541777. †Tulsa 1000 Investigator. IF: 6.2
  124. Lapidus RC, Puhl M, Kuplicki R, Stewart JL, Tulsa 1000 Investigators, Paulus MP, Rhudy JL, Khalsa SS. Heightened affective response to perturbation of respiratory but not pain signals in eating, mood, and anxiety disorders. PLoS One 2020 15(7):e0235346. doi: 10.1371/journal.pone.0235346. PMID: 32667951. IF: 2.8
  125. Stewart JL, White EJ, Kuplicki R, Akeman E, Bodurka J, Cha YH, Feinstein JS, Khalsa SS, Savitz J, Victor TA, Paulus MP, & Aupperle RL. Women with major depressive Disorder, irrespective of comorbid anxiety disorders, show blunted bilateral frontal responses during win and loss anticipation. Journal of Affective Disorders 2020 273, 157-166. doi: 10.1016/j.jad.2020.04.064. PMID: 32421596. IF: 4.8
  126. Dusi V, Shahabi L, Lapidus RC, Sorg JM, Naliboff BD, Shivkumar K, Khalsa SS, Ajijola OA. Cardiovascular autonomic reflex function following bilateral cardiac sympathetic denervation for ventricular arrhythmias. Heart Rhythm 2020 17(8):1320-1327. doi: 10.1016/j.hrthm.2020.04.022. PMID: 32325196. IF: 6.3
  127. DeVille DC, Kuplicki R, Stewart JL; Tulsa 1000 Investigators, Aupperle RL, Bodurka J, Cha YH, Feinstein J, Savitz JB, Victor TA, Paulus MP, Khalsa SS. Diminished responses to bodily threat and blunted interoception in suicide attempters. Elife. 2020 Apr 7;9. pii: e51593. doi: 10.7554/eLife.51593. PMID: 32254020. IF: 8.1
  128. DeVille DC, Whalen D, Breslin FJ, Morris AS, Khalsa SS, Paulus MP, Barch DM. Prevalence and Family-Related Factors Associated With Suicidal Ideation, Suicide Attempts, and Self-injury in Children Aged 9 to 10 Years. JAMA Network Open 2020 3(2):e1920956. doi: 10.1001/jamanetworkopen.2019.20956. PMID: 32031652. IF: 8.5
  129. Aupperle RL, Paulus MP, Kuplicki R, Touthang J, Victor T, Yeh H, Tulsa 1000 Investigators, Khalsa SS. Web-based graphic representation of the life course of mental health: cross-sectional study across the spectrum of mood, anxiety, eating, and substance use disorders. JMIR Mental Health 2020 7(1):e16919. doi: 10.2196/16919. PMID: 32012081. IF: 4.4
  130. Khalsa SS, Rudrauf D, Hassanpour MS, Davidson RJ, Tranel D. The practice of meditation is not associated with improved interoceptive awareness of the heartbeat. Psychophysiology 2020 57(2):e13479. doi: 10.1111/psyp.13479. PMID: 31573689. IF: 4.0
  131. Smith R, Khalsa SS, Paulus MP. An active inference approach to dissecting reasons for non-adherence to antidepressants. Biological Psychiatry: Cognitive Neuroscience and Neuroimaging Dec 5:S2451-9022(19)30309-X. doi: 10.1016/j.bpsc.2019.11.012. PMID: 32044234. IF: 6.2
  132. Ralph-Nearman C, Arevian AC, Puhl M, Kumar R, Villaroman D, Suthana N, Feusner JD, Khalsa SS. A novel mobile tool (Somatomap) to assess body image perception pilot tested with fashion models and nonmodels: cross-sectional study. JMIR Mental Health 6(10):e14115. doi: 10.2196/14115.PMID: 31469647. IF: 4.4
  133. Stewart JL, Khalsa SS, Kuplicki R, Puhl M, T1000 Investigators, Paulus MP. Interoceptive attention in opioid and stimulant use disorder. Addiction Biology 16:e12831. doi: 10.1111/adb.12831. PMID: 31617639. IF: 4.3
  134. Samad M, Ralph-Nearman C, Helleman G, Khalsa SS, Shams L, Feusner JD. Disturbed eating and body dysmorphic symptoms in a nonclinical sample are separable constructs each with bimodal distributions. Assessment Oct 14:1073191119879241. doi: 10.1177/1073191119879241. PMID: 31609131. IF: 4.3
  135. Murphy J, Brewer R, Plans D, Khalsa SS, Catmur C, Bird G. Testing the independence of self-reported interoceptive accuracy and attention. Quarterly Journal of Experimental Psychology 2020 73(1):115-133. doi: 10.1177/1747021819879826. PMID: 31519137. IF: 2.3
  136. Paulus MP, Feinstein JS, Khalsa SS. An active inference approach to interoceptive psychopathology. Annual Review of Clinical Psychology 2019 15: 97-122. doi: 10.1146/annurev-clinpsy-050718-095617. PMID: 31067416. IF: 19.9
  137. Clausen AN, Aupperle RL, Yeh H, Waller D, Payne J, Kuplicki R, Akeman E, Paulus MP, Tulsa 1000 Investigators† Machine learning analysis of the relationships between gray matter volume and childhood trauma in a transdiagnostic community-based sample. Biological Psychiatry Cognitive Neuroscience and Neuroimaging 2019 4:734-742. †Tulsa 1000 Investigator. doi: 10.1016/j.bpsc.2019.03.001. PMID: 31053534. IF: 6.2
  138. Al Zoubi, Mayeli A, Tsuchiyagaito A, Misaki M, Zotev V, Refai H, Paulus M, Bodurka J, Tulsa 1000 Investigators† EEG Microstates Temporal Dynamics Differentiate Individuals with Mood and Anxiety Disorders From Healthy Subjects. Frontiers in Human Neuroscience 2019 13:56. †Tulsa 1000 Investigator. doi: 10.3389/fnhum.2019.00056. PMID: 30863294. IF: 2.7
  139. Khalsa SS. Interoception in eating disorders: a clinical primer. Psychiatric Times 2019 36(9): 31-37.
  140. Maier A, Scheele D, Spengler F, Menba T, Mohr F, Güntürkün O, Stoffel-Wagner B, Kinfe T, Maier W, Khalsa SS, Hurlemann R. Oxytocin reduces a chemosensory-induced stress bias in social perception. Neuropsychopharmacology 2019, 44: 281-288. doi: 10.1038/s41386-018-0063-3. PMID: 29703998. IF: 7.9
  141. Le TT, Kuplicki R, McKinney BA, Yeh HW, Thompson WK, Paulus MP, Tulsa 1000 Investigators†. A Nonlinear Simulation Framework Supports Adjusting for Age When Analyzing BrainAGE. Front Aging Neurosci. 2018 10:317. doi: 10.3389/fnagi.2018.00317. PMID: 30405393 †Tulsa 1000 Investigator. IF: 4.4
  142. Khalsa SS, Hassanpour MS, Strober MA, Craske MG, Arevian AC, Feusner JD. Interoceptive anxiety and body representation in anorexia nervosa. 2018 Frontiers in Psychiatry 9:444. IF: 2.8
  143. Le TT, Kuplicki R, Yeh H, Aupperle RL, Khalsa SS, Simmons WK, Paulus MP. Effect of Ibuprofen on BrainAGE: a randomized, placebo-controlled, dose-response exploratory study. Biological Psychiatry Cognitive Neuroscience and Neuroimaging 2018, 3: 836-843. doi: 10.1016/j.bpsc.2018.05.002. PMID: 29941380. IF: 5.3
  144. Rangaprakash D, Bohon C, Lawrence KE, Moody T, Morfini F, Khalsa SS, Strober M, Feusner JD. Aberrant Dynamic Connectivity for Fear Processing in Anorexia Nervosa and Body Dysmorphic Disorder. 2018 Frontiers in Psychiatry 9:273. doi: 10.3389/fpsyt.2018.00273. PMID: 29997532. IF: 2.8
  145. DeVille DC, Kerr KL, Avery JA, Burrows K, Bodurka J, Feinstein J, Khalsa SS, Paulus MP, Simmons WK. The Neural Bases of Interoceptive Encoding and Recall in Healthy and Depressed Adults. Biological Psychiatry Cognitive Neuroscience and Neuroimaging 2018, 3: 546-54. doi: 10.1016/j.bpsc.2018.03.010. PMID: 29724684. IF: 6.2
  146. Feinstein JS, Khalsa SS, Yeh H, Al Zoubi O, Arevian AC, Wohlrab C, Pantino MK, Cartmell LJ, Simmons WK, Stein MB, Paulus MP. The elicitation of relaxation and interoceptive awareness using floatation therapy in individuals with high anxiety sensitivity. Biological Psychiatry Cognitive Neuroscience and Neuroimaging 2018, 3: 555-62. doi: 10.1016/j.bpsc.2018.02.005. PMID: 29656950. IF: 6.2
  147. Khalsa SS, Adolphs R, Cameron OG, Critchley HD, Davenport PW, Feinstein JS, Feusner JD, Garfinkel SN, Lane RD, Mehling WE, Meuret AE, Nemeroff CB, Oppenheimer S, Petzschner FH, Pollatos O, Rhudy JL, Schramm LP, Simmons WK, Stein MB, Stephan KE, Van Den Bergh O, Van Diest I, von Leupoldt A, Paulus MP, Interoception Summit 2016 Participants. Interoception and Mental Health: A Roadmap. Biological Psychiatry: Cognitive Neuroscience and Neuroimaging 2018, 3: 501-13. doi: 10.1016/j.bpsc.2017.12.004. PMID: 29884281. IF: 6.2. Most cited publication in the journal.
  148. Khalsa SS, Feinstein JS, Simmons WK, Paulus MP. Taking aim at interoception’s role in mental health. Biological Psychiatry Cognitive Neuroscience and Neuroimaging 2018, 3: 496-8. doi: 10.1016/j.bpsc.2018.04.007. PMID: 29884279. IF: 6.2
  149. Hassanpour MS, Luo Q, Simmons WK, Feinstein JS, Paulus M, Luh W, Bodurka J, Khalsa SS. Cardiorespiratory noise correction improves the ASL signal. Human Brain Mapping 2018, 39: 2353-67. doi: 10.1002/hbm.24000. PMID: 29450932. IF: 5.0
  150. Victor TA, Khalsa SS, Simmons WK, Feinstein JS, Savitz J, Aupperle RL, Yeh H, Bodurka J, Paulus MP. The Tulsa 1000: A naturalistic study protocol for multi-level assessment and outcome prediction in a large psychiatric sample. BMJ Open 2018 8:e016620. doi: 10.1136/bmjopen-2017-016620. PMID: 29371263. IF: 2.5
  151. Hassanpour MS, Luo Q, Feinstein JS, Simmons WK, Bodurka J, Paulus MP, Khalsa SS. The insular cortex dynamically maps changes in cardiorespiratory interoception. Neuropsychopharmacology 2018 43: 426-434. doi: 10.1038/npp.2017.154. PMID: 28726799. IF: 7.9
  152. Feinstein JS, Khalsa SS, Yeh H, Wohlrab C, Simmons WK, Stein MB, Paulus MP. Examining the short-term anxiolytic and antidepressant effect of Floatation-REST. PLoS One 2017 13:e0190292. doi: 10.1371/journal.pone.0190292. PMID: 29394251. IF: 3.2
  153. Khalsa SS, Portnoff LC, McCurdy-McKinnon D, Feusner JD. What happens after treatment? A systematic review of relapse, remission, and recovery in anorexia nervosa. Journal of Eating Disorders 2017 5: 20. doi: 10.1186/s40337-017-0145-3. PMID: 28630708. IF: 2.8. Received the Editor’s award due to the highest citation count for 2017-2019.
  154. Smith R, Thayer JF, Khalsa SS, Lane RD. The hierarchical basis of neurovisceral integration. Neuroscience and Biobehavioral Reviews. 2017 75: 274–296. doi: 10.1016/j.neubiorev.2017.02.003. PMID: 28188890. IF: 8.3
  155. Avery JA, Burrows K, Kerr KL, Khalsa SS, Bodurka J, Paulus MP, & Simmons WK. How the brain wants what the body needs: the neural basis of positive alliesthesia. Neuropsychopharmacology. 2017 42: 822-30. doi: 10.1038/npp.2016.128. PMID: 27427215. IF: 7.9
  156. Hassanpour MS, Yan LR, Wang, DJ, Lapidus RC, Arevian AC, Simmons WK, Feusner JD, Khalsa SS. How the heart speaks to the brain: neural activity during cardiorespiratory interoceptive stimulation. Philosophical Transactions of the Royal Society B. 2016 371: 20160017. doi: 10.1098/rstb.2016.0017. PMID: 28080974. IF: 6.7
  157. Khalsa SS, Lapidus R. Can interoception improve the pragmatic search for biomarkers in psychiatry? Frontiers in Psychiatry 2016 7:121. doi: 10.3389/fpsyt.2016.00121. PMID: 27504098. IF: 2.8
  158. Khalsa SS, Kumar R, Patel V, Strober M, Feusner, JD. Mammillary body volume abnormalities in anorexia nervosa. International Journal of Eating Disorders. 2016 49: 920-9. doi: 10.1002/eat.22573. PMID: 27414055. IF: 3.7
  159. Zhang A, Leow A, Zhan L, GadElkarim J, Moody T, Khalsa S, Strober M, Feusner JD. Brain connectome modularity in weight-restored anorexia nervosa and body dysmorphic disorder. Psychological Medicine. 2016 46: 2785-97. doi: 10.1017/S0033291716001458. PMID: 27429183. IF: 5.8
  160. Shivkumar K, Ajijola OA, Anand I, Armour JA, Chen PS, Esler MD, DeFerrari G, Fishbein MC, Goldberger JJ, Harper RM, Joyner MJ, Khalsa SS, Kumar R, Lane RD, Mahajan A, Po S, Schwartz PJ, Somers V, Valderrabano M, Vaseghi M, Zipes D. Clinical Neurocardiology—defining the value of neuroscience based cardiovascular therapeutics. Journal of Physiology. 2016 594: 3911-54. doi: 10.1113/JP271870. PMID: 27114333. IF: 5.2
  161. Khalsa SS, Feinstein JS, Li W, Feusner JD, Adolphs R, Hurlemann R. Panic anxiety in humans with bilateral amygdala lesions: pharmacological induction via cardiorespiratory interoceptive pathways. Journal of Neuroscience. 2016 36: 3559-66. doi: 10.1523/JNEUROSCI.4109-15.2016. PMID: 27013684. IF: 6.2
  162. Feinstein, JS, *Khalsa SS, Salomons TV, Prkachin KM, Frey-Law LA, Lee JE, Tranel D, Rudrauf D. Preserved emotional awareness of pain in a patient with extensive bilateral damage to the insula, anterior cingulate, and amygdala. Brain Structure and Function. 2016 221: 1499-511. doi: 10.1007/s00429-014-0986-3. PMID: 25577137. IF: 3.8
  163. Khalsa SS, Rudrauf D, Davidson RJ, Tranel D. The effect of meditation on regulation of internal body states. Frontiers in Psychology 6: 924. doi: 10.3389/fpsyg.2015.00924. PMID: 26217263. IF: 2.1
  164. Khalsa SS, Craske MG, Li W, Vangala S, Strober M, Feusner JD. Altered interoceptive awareness in anorexia nervosa: effects of meal anticipation, consumption and bodily arousal. International Journal of Eating Disorders. 2015 48: 889-97. doi: 10.1002/eat.22387. PMID: 25712775. IF: 3.7
  165. Li W, Lai TM, Loo SK, Strober M, Mohammad-Rezazadeh I, Khalsa S, Feusner J. Aberrant early visual neural activity and brain-behavior relationships in anorexia nervosa and body dysmorphic disorder. Front Hum Neurosci. 2015 9: 301. doi: 10.3389/fnhum.2015.00301. PMID: 26082703. IF: 2.7
  166. Feusner JD, Moody T, Lai TM, Sheen C, Khalsa S, Brown J, Levitt J, Alger J, O’Neill J. Brain connectivity and prediction of relapse after cognitive-behavioral therapy in obsessive-compulsive disorder. Front Psychiatry. 2015 6: 74. doi: 10.3389/fpsyt.2015.00074. PMID: 26042054. IF: 2.8
  167. Khalsa SS, Shahabi L, Ajijola OA, Bystritsky A, Naliboff BD, Shivkumar K. Synergistic application of cardiac sympathetic decentralization and comprehensive psychiatric treatment in the management of anxiety and electrical storm. Frontiers in Integrative Neuroscience (2014) 7: 1-14. doi: 10.3389/fnint.2013.00098. PMID: 2442712. IF: 2.2
  168. Bystritsky A, Khalsa SS, Cameron M, Schiffman J. Current Diagnosis and Treatment of Anxiety Disorders. Pharmacy and Therapeutics (2013) 38: 30-57. PMID: 23599668.
  169. Philippi C, Feinstein JS, Khalsa SS, Tranel D, Landini G, Williford K, Rudrauf D. Preserved self-awareness following extensive bilateral brain damage to the insula, anterior cingulate, and medial prefrontal cortices. PLoS One (2012) 7: e38413. doi: 10.1371/journal.pone.0038413. PMID: 22927899. IF: 3.2
  170. Khalsa SS, Schiffman J, Bystritsky A. Treatment-resistant OCD: Options beyond first line medications. Current Psychiatry (2011) 10: 45-52.
  171. Khalsa SS, Rudrauf D, Feinstein JS, & Tranel D. The pathways of interoceptive awareness. Nature Neuroscience (2009) 12: 1494-6. doi: 10.1038/nn.2411. PMID: 19881506. IF: 21.4
  172. Khalsa SS, Rudrauf D & Tranel D. Interoceptive awareness declines with age. Psychophysiology (2009) 46: 1130-6. doi: 10.1111/j.1469-8986.2009.00859.x. PMID: 19602175. IF: 4.0.
  173. Feinstein JS, Rudrauf D, Khalsa SS, Cassell M, Bruss J, Grabowski TJ & Tranel D. Bilateral limbic system destruction in man. Journal of Clinical and Experimental Neuropsychology (2009) 17: 1-19. doi: 10.1080/13803390903066873. PMID: 19763994 IF: 2.0
  174. Khalsa SS, Rudrauf D, Sandesara C, Olshansky B & Tranel D. Bolus isoproterenol infusions provide a reliable method for assessing interoceptive awareness. International Journal of Psychophysiology (2009) 72: 34-45. doi: 10.1016/j.ijpsycho.2008.08.010. PMID: 18854201. IF: 3.0
  175. Khalsa SS, Rudrauf D, Damasio AR, Davidson RJ, Lutz A & Tranel D. Interoceptive awareness in experienced meditators. Psychophysiology (2008) 45: 671-8. doi: 10.1111/j.1469-8986.2008.00666.x. PMID: 18503485. IF: 4.0
  176. Khalsa SS, Moore SA & Van Hoesen GW. Hughlings Jackson and the role of the entorhinal cortex in temporal lobe epilepsy: from Patient A to Doctor Z. Epilepsy and Behavior (2006) 9: 524-31. doi: 10.1016/j.yebeh.2006.07.017. PMID: 16942917. IF: 2.5
  177. Goldstein RZ, Leskovjan AC, Hoff AL, Hitzemann R, Bashan F, Khalsa SS, Wang GJ, Fowler JS & Volkow ND. Severity of neuropsychological impairment in cocaine and alcohol addiction: association with metabolism in the prefrontal cortex. Neuropsychologia (2004) 42: 1447-58. doi: 10.1016/j.neuropsychologia.2004.04.002. PMID: 15246283. Impact factor (IF): 2.9
  1. Khalsa SS & Feinstein JS (2018). The somatic error hypothesis of anxiety. In M. Tsakiris & H. De Preester (Eds.), The Interoceptive Mind: From Homeostasis to Awareness (pp. 144-64). New York: Oxford University Press.
  2. Smith R & Khalsa SS (2023). Interpreting the signals within: Meaning and prediction during interoception. In A. Garcia & A. Ibáñez (Eds.), Routledge Handbook of Neurosemiotics (pp. 375-386). New York: Routledge Press.
  3. Verdonk C & Khalsa SS (2024). Interoception and mental health. In J. Murphy & R. Brewer (Eds.), Interoception: A Comprehensive Guide. Springer Nature.
  4. Choquette E & Khalsa SS (2025). The neurobiology of interoception in eating disorders. In J. Steinglass & C. Wierenga (Eds.), Handbook of the Neurobiology of Eating Disorders. New York: Oxford University Press.
  5. Powers AR & Khalsa SS (2025). The Future of Perceptual Dysregulation in Psychiatric Nosology. In S. S. Khalsa & A. R. Powers (Eds.), Perceptual Dysregulation in Psychiatric Nosology (Current Topics in Behavioral Neurosciences). Springer.

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