Dr. Khalsa co-authored a landmark perspective in Gastroenterology (Impact Factor 25.1), one of the highest-ranked journals in the field of digestive diseases.
The paper, titled “Gut Feelings: The Critical Role of Interoception in Obesity and Disorders of Gut-Brain Interaction,” was published in Volume 169, Issue 2 (August 2025) alongside co-authors Lin Chang (UCLA), Christoph A. Thaiss (Stanford University), and Zachary Knight (UCSF).
This publication grew out of the NIDDK-sponsored workshop “Gut Feelings: Interoceptive Contributions to Obesity and Disorders of Gut-Brain Interaction,” held April 30–May 1, 2024, in North Bethesda, Maryland. Dr. Khalsa delivered the keynote presentation on “Gastrointestinal Interoception in Health and Disease” at the workshop, which brought together leading experts in interoception, obesity, and gut-brain disorders.
The paper examines:
- How the nervous system senses, interprets, and integrates signals from within the body
- The role of interoceptive processes in obesity and disorders of gut-brain interaction (DGBI)
- Neural sensing pathways that control food intake and gut-brain signaling
- Technologies for measuring and modulating gut-brain interactions
- Potential therapeutic targets and neuromodulatory approaches
The full text is available on PubMed (PMID: 40250772, DOI: 10.1053/j.gastro.2025.04.002).